AOD-9604
Overview
A modified fragment of the C-terminus of human growth hormone investigated in lipolysis research without the glucose-handling effects associated with full-length hGH.
Research profile · for clinicians
Based on research: a growth-hormone C-terminal fragment investigated for lipolytic (fat-releasing) activity without the glucose-handling effects of full-length GH. Discussed in obesity and adipocyte-metabolism literature, though the Phase II program did not advance.
Mechanism of action
Proposed activation of β3-adrenergic-receptor pathways stimulating lipolysis and inhibiting lipogenesis in preclinical adipocyte studies, independent of GH-receptor signaling.
Research record
- [01]Phase II investigation in obesity cohorts (program discontinued).
Selected references
AOD9604 and adipose tissue metabolism
Trends Endocrinol. Metab., 2001