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Reproductive & Neuroendocrine

Kisspeptin-10

Also known as · KP-10 · Metastin fragment 45-54

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Overview

The shortest bioactive fragment of kisspeptin, the master upstream regulator of GnRH release — a discovery that reshaped understanding of how puberty is initiated.

Research profile · for clinicians

Based on research: studied in human trials at Imperial College for hypothalamic amenorrhoea, male sexual response, and safer ovulation triggering in IVF.

Mechanism of action

Activates KISS1R on hypothalamic GnRH neurons, evoking physiological GnRH pulses that in turn drive pituitary LH and FSH release — an upstream, more physiological lever than direct gonadotropin dosing.

Research record

  • [01]Kisspeptin triggering of oocyte maturation in IVF with reduced hyperstimulation risk.
  • [02]Enhanced limbic activation to sexual stimuli in men (JCI, 2017).

Selected references

  • Kisspeptin modulates sexual and emotional brain processing in humans

    J. Clin. Invest., 2017

Research deep dive

Every cited study, explained

Plain-language walkthroughs of each reference, with direct PubMed links and dosing-literature context.