Thymosin α1
Also known as · Tα1 · Thymalfasin
Overview
A 28-amino-acid acetylated peptide originally isolated from calf thymus. Investigated as an immunomodulator in chronic viral hepatitis and certain malignancy research programs internationally.
Research profile · for clinicians
Based on research: studied as an immune-tuning peptide. Rather than broadly suppressing or stimulating immunity, it is examined for helping T-cell maturation and dendritic-cell signaling — used adjunctively in chronic viral hepatitis and vaccine-response research, particularly in older cohorts.
Mechanism of action
Activates TLR-mediated dendritic-cell signaling, promotes Th1 cytokine profile, and supports T-cell differentiation from precursor populations.
Research record
- [01]Adjunctive use studies in chronic hepatitis B research.
- [02]Investigations as a vaccine adjuvant in elderly cohorts.
Selected references
Thymosin alpha 1: past clinical experience and future paradigms
Ann. NY Acad. Sci., 2010