5-Amino-1MQ

Also known as · 5-amino-1-methylquinolinium

Overview

A small, orally available NNMT inhibitor studied for increasing intracellular NAD+ in adipose tissue and reducing fat-cell size in obese rodent models. Non-peptidic, included for completeness of the metabolic-longevity class.

Research profile · for clinicians

Based on research: preclinical only. Mouse studies report reduced adipocyte size and body weight without changed food intake, via a salvage-pathway increase in NAD+.

Mechanism of action

Inhibits NNMT, the enzyme that methylates nicotinamide for excretion, conserving nicotinamide for the NAD+ salvage pathway and raising intracellular NAD+ in white adipose tissue.

Research record

[01]Reduced adipocyte size and body weight in diet-induced obese mice (Neelakantan et al., 2018).
[02]No human trials published.

Selected references

Selective and membrane-permeable small molecule inhibitors of NNMT
Biochem. Pharmacol., 2018

Research deep dive

Every cited study, explained

Plain-language walkthroughs of each reference, with direct PubMed links and dosing-literature context.