MOTS-c
Overview
A 16-amino-acid peptide encoded within the mitochondrial 12S rRNA region. Investigated for AMPK-mediated metabolic effects and exercise-mimetic profiles in preclinical models. Commonly researched on a 5-day cycle with one vial allocated every 3 weeks.
Research profile · for clinicians
Based on research: a mitochondrial-derived peptide studied as an exercise-mimetic and metabolic regulator. Investigations report AMPK pathway activation, improved insulin sensitivity in aged mice, and preserved exercise capacity. Typical research protocol: a 5-day administration cycle, with one bottle used approximately every 3 weeks.
Mechanism of action
Activates AMPK and modulates folate-methionine-purine flux; under metabolic stress, translocates to the nucleus to regulate adaptive gene expression.
Research record
- [01]Improved insulin sensitivity in aged mouse models (Lee et al., 2015).
- [02]Exercise capacity and metabolic homeostasis preclinical studies.
Selected references
The mitochondrial-derived peptide MOTS-c
Cell Metab., 2015