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Longevity & Mitochondrial

NAD+

Also known as · Nicotinamide Adenine Dinucleotide

Overview

An essential pyridine dinucleotide coenzyme central to redox metabolism and signaling. Included here for completeness — frequently administered parenterally in longevity-medicine settings despite limited high-quality clinical efficacy data.

Research profile · for clinicians

Based on research: an essential coenzyme central to redox metabolism, sirtuin activity, and DNA repair (PARPs). Frequently administered in longevity settings to address the age-related decline in tissue NAD+, though controlled clinical data on IV administration remain limited.

Mechanism of action

Serves as electron carrier in oxidative phosphorylation; provides substrate for sirtuin deacetylases (SIRT1-7), PARP DNA-repair enzymes, and CD38. Tissue NAD+ declines with age in multiple species.

Research record

  • [01]NAD+ precursor (NR, NMN) supplementation trials in healthy adults.
  • [02]Limited controlled data on direct IV NAD+ administration; mostly observational.

Selected references

  • NAD+ in aging, metabolism, and neurodegeneration

    Science, 2015