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All Info Peptides
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Healing & Tissue Repair

ARA-290

Also known as · Cibinetide

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Overview

An 11-amino-acid peptide derived from erythropoietin's helix B that activates tissue-protective signalling without any erythropoietic effect — studied notably in small-fibre neuropathy.

Research profile · for clinicians

Based on research: one of the few repair peptides with randomised human data. Trials in sarcoidosis-associated small-fibre neuropathy reported improved corneal nerve-fibre measures and pain scores.

Mechanism of action

Selectively engages the EPOR/CD131 innate repair receptor, activating JAK2/STAT3 anti-apoptotic and anti-inflammatory signalling in neurons and endothelium while sparing the classical EPO receptor.

Research record

  • [01]Randomised trials in sarcoidosis small-fibre neuropathy: improved neuropathic symptoms.
  • [02]Type 2 diabetes neuropathy studies reported increased corneal nerve fibre density.

Selected references

  • ARA 290 improves symptoms in patients with sarcoidosis-associated small nerve fiber loss

    Mol. Med., 2014

Research deep dive

Every cited study, explained

Plain-language walkthroughs of each reference, with direct PubMed links and dosing-literature context.