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Healing & Tissue Repair

BPC-157

Also known as · Body Protection Compound 157 · PL 14736

Overview

A synthetic pentadecapeptide derived from a protective protein found in gastric juice. Extensively studied in rodent models for its angiogenic, cytoprotective, and tendon/ligament repair properties.

Research profile · for clinicians

Based on research: studied primarily as a tissue-repair candidate. Preclinical work centers on tendon, ligament, muscle, and gut-lining healing — the underlying signals investigated include new blood-vessel formation (angiogenesis), nitric-oxide balance, and fibroblast migration into damaged tissue. Frequently referenced in orthopedic and gastrointestinal recovery literature.

Mechanism of action

Preclinical evidence suggests upregulation of VEGFR2 expression and nitric-oxide–mediated vasodilation. Promotes early outgrowth of tendon fibroblasts and modulates the dopaminergic and serotonergic systems in animal models.

Research record

  • [01]Accelerated Achilles tendon-to-bone healing in rat models (Krivic et al., 2006).
  • [02]Cytoprotection against NSAID-induced gastrointestinal lesions in rats.
  • [03]Modulation of nitric-oxide system in models of vascular injury.

Selected references

  • Stable gastric pentadecapeptide BPC 157 in clinical trials

    Curr. Pharm. Des., 2010

  • Brain-gut axis and BPC 157

    Biomedicines, 2021