TB-500
Also known as · Thymosin Beta-4 fragment
Overview
A short synthetic peptide derived from the actin-binding region of Thymosin β4. Investigated in models of corneal injury, dermal wound healing, and post-infarct cardiac remodeling.
Research profile · for clinicians
Based on research: investigated as a systemic tissue-repair and cell-migration modulator. The active fragment binds actin inside cells, which is a key step in how endothelial and stem-like cells crawl into injured tissue. Preclinical models most often examine dermal wound closure, corneal healing, and post-infarct cardiac remodeling.
Mechanism of action
The LKKTET sequence binds G-actin monomers, regulating cytoskeletal organization, endothelial cell migration, and angiogenesis in injured tissue.
Research record
- [01]Improved ejection fraction in murine post-MI models (Bock-Marquette et al., 2004).
- [02]Accelerated dermal wound closure in diabetic mouse models.
- [03]Phase II investigations in epidermolysis bullosa and dry eye disease.
Selected references
Thymosin β4 activates integrin-linked kinase
Nature, 2004
Tβ4 in tissue regeneration
Ann. NY Acad. Sci., 2012