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All Info Peptides
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Longevity & Mitochondrial

FOXO4-DRI

Also known as · FOXO4 D-retro-inverso peptide

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Overview

A protease-resistant designer peptide that selectively kills senescent cells by breaking the FOXO4-p53 interaction that keeps them alive, studied as a prototype senolytic.

Research profile · for clinicians

Based on research: one landmark rodent paper reported restored fitness, fur density, and renal function in aged and progeroid mice. Human data do not exist, and off-target apoptosis is the central open question.

Mechanism of action

Competitively disrupts FOXO4 binding to p53, releasing p53 to the cytoplasm where it triggers apoptosis specifically in senescent cells that depend on that interaction for survival.

Research record

  • [01]Baar et al. (Cell, 2017): targeted apoptosis of senescent cells restored tissue homeostasis in mice.
  • [02]No human trials; selectivity and dosing in humans are unestablished.

Selected references

  • Targeted apoptosis of senescent cells restores tissue homeostasis

    Cell, 2017

Research deep dive

Every cited study, explained

Plain-language walkthroughs of each reference, with direct PubMed links and dosing-literature context.