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All Info Peptides
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Growth Hormone Secretagogues

GHRP-6

Also known as · Growth Hormone Releasing Peptide-6

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Overview

The original growth hormone-releasing hexapeptide and the compound that led to the discovery of the ghrelin receptor. Notable for pronounced appetite stimulation alongside GH release.

Research profile · for clinicians

Based on research: historically important as the probe that identified GHS-R1a. Studied for GH secretion, hunger signalling, and cytoprotective effects in cardiac and gastric injury models.

Mechanism of action

GHS-R1a agonism on pituitary somatotrophs drives GH pulses; the same receptor in the arcuate nucleus drives NPY/AgRP-mediated hunger, which is why appetite increase is prominent.

Research record

  • [01]Cytoprotective effects reported in preclinical models of ischaemic injury.
  • [02]Reliable GH pulse induction in human provocative testing.

Selected references

  • Growth hormone-releasing peptides: clinical and basic aspects

    Endocr. Rev., 1997

Research deep dive

Every cited study, explained

Plain-language walkthroughs of each reference, with direct PubMed links and dosing-literature context.