Category
Growth Hormone Secretagogues
Ghrelin-receptor agonists and GHRH analogues studied for endogenous GH/IGF-1 axis modulation.
Growth Hormone Secretagogues
CJC-1295
DAC:GRF · Modified GRF (1-29)
- MW
- 3367.9 g/mol (with DAC)
- Half-life
- ≈ 8 days (with DAC); ≈ 30 min (without)
- Class
- GHRH analogue (with or without Drug Affinity Complex)
Growth Hormone Secretagogues
Follistatin-344
FS-344 · FST
- MW
- ≈ 38 kDa
- Half-life
- Minutes to a few hours (rapid clearance)
- Class
- Activin-binding glycoprotein (myostatin inhibitor)
Growth Hormone Secretagogues
GHRP-2
Pralmorelin · KP-102
- MW
- 817.0 g/mol
- Half-life
- ≈ 30 min
- Class
- Synthetic growth hormone-releasing hexapeptide
Growth Hormone Secretagogues
GHRP-6
Growth Hormone Releasing Peptide-6
- MW
- 873.0 g/mol
- Half-life
- ≈ 20–30 min
- Class
- Synthetic growth hormone-releasing hexapeptide
Growth Hormone Secretagogues
Hexarelin
- MW
- 887.05 g/mol
- Half-life
- ≈ 70 min (IV)
- Class
- Synthetic GH-releasing hexapeptide (GHRP)
Growth Hormone Secretagogues
IGF-1 DES(1-3)
DES(1-3) IGF-1
- MW
- 7371 g/mol
- Half-life
- ≈ 20–30 min
- Class
- Truncated IGF-1 analogue
Growth Hormone Secretagogues
IGF-1 LR3
Long-R3-IGF-1
- MW
- 9111 g/mol
- Half-life
- ≈ 20–30 h (extended vs. native IGF-1)
- Class
- Modified recombinant insulin-like growth factor 1
Growth Hormone Secretagogues
Ipamorelin
- MW
- 711.86 g/mol
- Half-life
- ≈ 2 h
- Class
- Selective ghrelin/GHS-R1a agonist
Growth Hormone Secretagogues
MGF
Mechano Growth Factor · IGF-1Ec
- MW
- 2867 g/mol
- Half-life
- Minutes (native form)
- Class
- IGF-1 splice variant E-domain peptide
Growth Hormone Secretagogues
MK-677
Ibutamoren · L-163,191
- MW
- 528.7 g/mol
- Half-life
- ≈ 4–6 h (once-daily dosing)
- Class
- Non-peptide oral ghrelin receptor agonist
Growth Hormone Secretagogues
PEG-MGF
Pegylated Mechano Growth Factor
- MW
- ≈ 2867 g/mol plus PEG moiety
- Half-life
- Hours to days (PEG-extended)
- Class
- PEGylated IGF-1Ec E-domain peptide
Growth Hormone Secretagogues
Sermorelin
GHRH(1-29) · GRF 1-29
- MW
- 3358 g/mol
- Half-life
- ≈ 10–20 min (SC)
- Class
- GHRH(1-29) analogue
Growth Hormone Secretagogues
Tesamorelin
- MW
- 5135.9 g/mol
- Half-life
- ≈ 26 min (SC)
- Class
- Stabilized GHRH(1-44) analogue