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Growth Hormone Secretagogues

Hexarelin

Overview

A potent synthetic ghrelin-receptor agonist with documented cardioprotective signaling in preclinical models, mediated in part through CD36 in cardiac tissue independent of GH release.

Research profile · for clinicians

Based on research: a potent GH-releasing peptide with a distinctive cardiac profile. Beyond GH release, preclinical ischemia-reperfusion models examine CD36-mediated cardioprotective signaling in cardiomyocytes — the basis for its cardiovascular-research references.

Mechanism of action

Strong GHS-R1a agonism produces robust GH pulses; concurrent CD36 binding in cardiomyocytes has been linked to cardioprotective effects in rodent ischemia-reperfusion models.

Research record

  • [01]Comparative GH-release studies vs. GHRP-6 and ipamorelin.
  • [02]Preclinical cardioprotection in ischemia-reperfusion models.

Selected references

  • Hexarelin and the cardiovascular system

    Cardiovasc. Res., 2007