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Growth Hormone Secretagogues

Sermorelin

Also known as · GHRH(1-29) · GRF 1-29

Overview

The shortest fragment of native GHRH that retains full biological activity. Historically used as a diagnostic and therapeutic agent in pediatric growth hormone deficiency.

Research profile · for clinicians

Based on research: the classic short-acting GHRH analogue, historically used in pediatric growth-hormone-deficiency diagnostics and treatment. Its short half-life is specifically studied for preserving natural pulsatile GH release and negative-feedback regulation.

Mechanism of action

Selective GHRH receptor agonism on anterior pituitary somatotrophs amplifies endogenous pulsatile GH release. Short half-life preserves physiologic pulsatility and feedback regulation.

Research record

  • [01]Pediatric growth-hormone deficiency clinical trials (1980s–1990s).
  • [02]GH-stimulation diagnostic testing literature.

Selected references

  • Sermorelin: a better approach to GH insufficiency?

    Clin. Interv. Aging, 2006