MGF
Also known as · Mechano Growth Factor · IGF-1Ec
Overview
The C-terminal E-domain peptide of the IGF-1Ec splice variant, expressed by skeletal muscle in response to mechanical loading and damage, and studied for satellite-cell activation.
Research profile · for clinicians
Based on research: studied in muscle-repair biology as the local, load-induced counterpart to systemic IGF-1. Preclinical focus on satellite-cell proliferation and myoblast recruitment.
Mechanism of action
Acts through an IGF-1R-independent pathway to trigger proliferation of quiescent satellite cells, expanding the myonuclear pool available for repair before differentiation signals take over.
Research record
- [01]Satellite-cell activation and myoblast proliferation in rodent muscle-damage models.
- [02]Rapid systemic degradation limits unmodified MGF to local research applications.
Selected references
Mechano-growth factor and muscle repair
J. Physiol., 2003
Research deep dive
Every cited study, explained
Plain-language walkthroughs of each reference, with direct PubMed links and dosing-literature context.