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All Info Peptides
All monographs

Longevity & Mitochondrial

Humanin

Also known as · HN · HNG (potent analogue)

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Overview

The first-described mitochondrial-derived peptide, encoded within mitochondrial 16S rRNA, with cytoprotective activity and circulating levels that fall with age.

Research profile · for clinicians

Based on research: a central molecule in mitochondrial-signalling and longevity biology. Higher circulating humanin correlates with longevity in human cohorts and with lifespan extension in animal models.

Mechanism of action

Binds a trimeric gp130/CNTFR/WSX-1 receptor complex and FPRL1 to activate STAT3 signalling, suppress Bax-mediated apoptosis, and improve insulin sensitivity and mitochondrial function.

Research record

  • [01]Circulating levels decline with age and are higher in offspring of centenarians.
  • [02]HNG analogue improved insulin sensitivity and neuroprotection in rodent models.

Selected references

  • Humanin: a mitochondrial-derived peptide in aging and disease

    Trends Endocrinol. Metab., 2013

Research deep dive

Every cited study, explained

Plain-language walkthroughs of each reference, with direct PubMed links and dosing-literature context.