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Cognitive & Neurotrophic

Dihexa

Also known as · N-hexanoic-Tyr-Ile-(6) aminohexanoic amide · PNB-0408

Overview

A small oligopeptide derived from the angiotensin IV scaffold, investigated in preclinical models of cognitive impairment for its reported ability to potentiate HGF/c-Met signaling and synaptogenesis. No human trial data are published.

Research profile · for clinicians

Based on research: an angiotensin-IV-derived oligopeptide studied preclinically for cognitive and synaptic effects. Reported to potentiate HGF/c-Met signaling and dendritic spine formation in hippocampal cultures and aged-rodent cognition models.

Mechanism of action

Reported to enhance HGF binding to the c-Met receptor, promoting dendritic spine formation and synaptogenesis in hippocampal cultures and aged rodent cognition models.

Research record

  • [01]Reversal of scopolamine-induced cognitive deficits in rats (Harding et al., 2012).
  • [02]No published human clinical trials.

Selected references

  • The angiotensin IV analog Dihexa as a procognitive agent

    J. Pharmacol. Exp. Ther., 2012