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Cognitive & Neurotrophic

PT-141

Also known as · Bremelanotide

Overview

A cyclic heptapeptide melanocortin-receptor agonist studied in CNS-mediated sexual response research. Acts on hypothalamic melanocortin circuits rather than vascular pathways.

Research profile · for clinicians

Based on research: studied as a centrally acting modulator of sexual response, distinct from vascular ED mechanisms. Acts on hypothalamic melanocortin circuits and has clinical trial data (RECONNECT) in premenopausal hypoactive sexual desire disorder.

Mechanism of action

Selective agonism of MC4R within hypothalamic nuclei modulates dopaminergic signaling associated with arousal pathways, independent of phosphodiesterase mechanisms.

Research record

  • [01]RECONNECT trials in pre-menopausal HSDD cohorts.

Selected references

  • Bremelanotide for hypoactive sexual desire disorder

    Obstet. Gynecol., 2019