Selank
Overview
A synthetic analogue of the immunomodulatory tetrapeptide tuftsin. Studied in anxiolytic and nootropic research in Russian clinical literature.
Research profile · for clinicians
Based on research: studied as a non-sedating anxiolytic and cognitive modulator. Comparative Russian clinical work looked at it alongside benzodiazepines for generalized anxiety, with mechanism studies pointing to GABA-receptor subunit modulation and enkephalin stabilization rather than direct sedation.
Mechanism of action
Inhibits enkephalin degradation and modulates expression of GABA-A receptor subunits in the hippocampus, producing anxiolytic profiles in rodent models without classical benzodiazepine effects.
Research record
- [01]Comparative anxiolytic studies vs. medazepam in clinical research.
- [02]Modulation of BDNF and enkephalin expression in preclinical models.
Selected references
Selank, an anxiolytic peptide
Bull. Exp. Biol. Med., 2008