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Cognitive & Neurotrophic

DSIP

Also known as · Delta Sleep-Inducing Peptide

Overview

A naturally occurring nonapeptide originally isolated for its ability to induce delta-wave EEG activity in rabbits. Investigated in stress, withdrawal, and sleep-architecture research; mechanism remains incompletely characterized.

Research profile · for clinicians

Based on research: a naturally occurring nonapeptide investigated for delta-wave sleep architecture, stress adaptation, and opioid-withdrawal support. Mechanism is not fully resolved, but effects on hypothalamic-pituitary-axis modulation are consistently reported.

Mechanism of action

Crosses the blood-brain barrier and modulates hypothalamic-pituitary axis activity; preclinical work suggests effects on stress hormone regulation and modulation of opioid withdrawal, though receptor target is not definitively established.

Research record

  • [01]Early human EEG sleep-architecture studies (1980s).
  • [02]Investigations in opioid and alcohol withdrawal protocols (Eastern European literature).

Selected references

  • Delta sleep-inducing peptide: a review

    Neurosci. Biobehav. Rev., 1984