P21
Also known as · P021 · Ciliary neurotrophic factor peptide mimetic
Overview
A small, blood-brain-barrier-penetrant peptide mimetic of ciliary neurotrophic factor, studied in rodent models of Alzheimer's disease for neurogenesis and reduced tau pathology.
Research profile · for clinicians
Based on research: entirely preclinical. Rodent work reports enhanced hippocampal neurogenesis, increased BDNF, and reduced tau hyperphosphorylation — with no human trials to date.
Mechanism of action
Mimics the active region of CNTF, increasing mature BDNF and TrkB signalling, promoting adult hippocampal neurogenesis, and inhibiting GSK-3β-driven tau phosphorylation.
Research record
- [01]Improved cognition and reduced tau pathology in 3xTg-AD mice.
- [02]No published human safety or efficacy data.
Selected references
A neurotrophic peptide mimetic rescues cognitive impairment in Alzheimer models
Neurobiol. Aging, 2013
Research deep dive
Every cited study, explained
Plain-language walkthroughs of each reference, with direct PubMed links and dosing-literature context.